THE HEPATOPROTECTIVE EFFECTS OF THE METHANOLIC EXTRACT FROM THE PANDANUS ODORATISSIMUS FRUIT EXPRIMENTED ON THE SWISS STRAIN OF MICE

Abstract

 The hepatoprotective effects of the methanolic fruit extract from the Pandanus odoratissimus fruit have been shown from an experiment on Swiss mice infected with paracetamol. The methanolic extract (100, 200 and 300 mg/kg body weight/day) was given orally to the mice for seven consecutive days. On the 8^th and 9^th days of the experiment, the mice were intoxicated with paracetamol (3g/kg body weight/day). Silymarin was served as a reference agent. The research results showed that the methanolic extract from the Pandanus odoratissimus fruit had a hepatoprotective effect against paracetamol-induced liver damage. The livers of the mice receiving the testing dose of 100 mg/kg/day were better protected than the ones receiving 200, 300 mg/kg/day. The Pandanus odoratissimus fruit methanolic extract with a concentration of 100 mg/kg body weight/day was capable of decreasing the plasma activeness of the aspartate amino transferase enzyme (AST) and the alanine amino transferase (ALT) enzyme 1,76 times and 2,12 times respectively as well as reducing malondialdehyde (MDA) concentration in an experiment against the lipid peroxidation of cell membranes compared to the control group of mice